研究について

研究について

研究内容

脳腫瘍の遺伝子解析
遺伝子治療の基礎研究
虚血性神経細胞死のメカニズムの解明
脳血管攣縮のメカニズムの解明
パーキンソン病の病態解明と治療法の開発
安全な手術支援のための術中モニタリング法の開発

教育業務

<医学部>
教養教育科目(身近な医学)
医学論文作成チュートリアル(2年生)
脳神経外科系統講義(4年生)
脳神経外科臨床実習(5年生)
実践臨床病態学講義(6年生)
<大学院>
脳脊髄病態外科学講義、脳脊髄病態外科学演習、脳脊髄病態外科学実習
脳神経外科的疾患の病態、治療法の研究の統合的理解を助けるため、セミナー形式の講義、研究指導、論文作成指導を行っている。

業績

Yamaguchi R , Tosaka M , Miyagishima T , Osawa T , Horiguchi K, Honda F , and Yoshimoto Y : Sagittal bending of the optic nerve at the entrance from the intracranial to the optic canal and ipsilateral visual acuity in patients with sellar and suprasellar lesions. J Neurosurg 134:180-188, 2021

Asano H, Shimizu T, Aihara M, Yamaguchi R, Aishima K, Yoshimoto Y: Acute Endovascular Revascularization for Patients with Common Carotid Artery Occlusion Apparent on Cervical Magnetic Resonance Angiography. Journal of Stroke and Cerebrovascular Diseases 30(4), 2021

Shimizu T, Aihara M, Yamaguchi R, Sato K, Aishima K, Yoshimoto Y: Large Craniotomy Increases the Risk of Minor Perioperative Complications in Revascularization Surgery for Moyamoya Disease. World Neurosurgery
141, e498-e507, 2020

Aihara M, Shimizu T, Naito I, Miyamoto N, Yoshimoto Y: Surgical Strategies and Clinical Results of Site-Specific Treatment Using High-Flow Bypass for Ruptured Blood Blister–Like Anterior Wall Aneurysms of the Internal Carotid Artery. World Neurosurgery 125, e1247-e1255, 2019

Miyagishima T, Tosaka M, Yamaguchi R, Nagaki T, Ishii N, Kojima T & Yoshimoto Y: Extended endoscopic endonasal resection of craniopharyngioma using intraoperative visual evoked potential monitoring: technical note. Acta Neurochirurgica 161, 2277–2284, 2019

Komiyama K , Tosaka M , Shimauchi-Ohtaki H , Aihara M , Shimizu T, and Yoshimoto Y : Computed tomography findings after head injury preceding chronic subdural hematoma. Neurosurg Focus 47(5) E12, 2019

Tosaka M, Shimizu T, Miyagishima T, Tanaka Y, Osawa T, Aihara M, Yamaguchi R & Yoshimoto Y: Combined supra-infrasellar approach to pituitary macroadenoma with oculomotor cistern extension: surgical strategy and experience. Acta Neurochirurgica 161, 1025–1031, 2019

Aihara M, Naito I , Shimizu T, Matsumoto M, Asakura K , Miyamoto N, and Yoshimoto Y: Predictive factors of medullary infarction after endovascular internal trapping using coils for vertebral artery dissecting aneurysms. J Neurosurg 129: 107-113, 2018

R Shintoku, M Tosaka, T Shimizu, and Y Yoshimoto: Transcranial and Epidural Approach for Spontaneous Cerebrospinal Fluid Leakage Due to Meningoencephalocele of the Lateral Sphenoid Sinus. Asian J Neurosurg.   13(2): 462–464,2018

Nakata S, Horiguchi K, Ishiuchi S, Yoshimoto Y, Yamada S, Nobusawa S, Ikota H, Hirato J, Yokoo H : A case of high-grade astrocytoma with BRAF and ATRX mutations following a long-standing course over two decades. Neuropathology. Feb 9, 2017

Horiguchi K, Tosaka M, Higuchi T, Arisaka Y, Sugawara K, Hirato J, Yokoo H, Tsushima Y, Yoshimoto Y : Clinical value of fluorine-18α-methyltyrosine PET in patients with gliomas: comparison with fluorine-18 fluorodeoxyglucose PET. EJNMMI Res. Dec;7(1):50,  2017

Tosaka M, Higuchi T, Horiguchi K, Osawa T, Arisaka Y, Fujita H, Tsushima Y, Yoshimoto Y : Preoperative Evaluation of Sellar and Parasellar Macro-lesions by Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography. World Neurosurg. Apr 17, 2017

Osawa S, Kurachi M, Yamamoto H, Yoshimoto Y, Ishizaki Y : Fibronectin on extracellular vesicles from microvascular endothelial cells is involved in the vesicle uptake into oligodendrocyte precursor cells. Biochem Biophys Res Commun. 488(1):232-238, 2017

Ibe Y, Tosaka M, Horiguchi K, Sugawara K, Miyagishima T, Hirato M, Yoshimoto Y: Resection extent of the supplementary motor area and post-operative neurological deficits in glioma surgery. Br J Neurosurg. Jan 13:1-7. [Epub ahead of print], 2016

Matsuzaki Y, Konno A, Mukai R, Honda F, Hirato M, Yoshimoto Y, Hirai H: Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors. Mol Neurobiol. Feb 16. [Epub ahead of print], 2016

Torii S, Shintoku R, Kubota C, Yaegashi M, Torii R, Sasaki M, Suzuki T, Mori M, Yoshimoto Y, Takeuchi T, Yamada K: An essential role for functional lysosomes in ferroptosis of cancer cells.Biochem J. 473:769-777, 2016

Yamaguchi R, Kohga H, Tosaka M, Sekine A, Mizushima K, Harigaya Y, Yoshimoto Y : A Case of Optic Neuritis Concomitant with Pituitary Tumor During Pregnancy. World Neurosurgery. Sep;93:488, 2016

Tanaka Y, Tosaka M, Fujimaki H, Honda F, Yoshimoto Y : Sex- and Age-Related Differences in the Clinical and Neuroimaging Characteristics of Patients With Spontaneous Intracranial Hypotension: A Records Review. Headache. Sep;56(8):1310-6, 2016

Aishima K, Shimizu T, Aihara M, Yoshimoto Y : Lifetime Effects of Small Unruptured Intracranial Aneurysms. World Neurosurg. Nov;95:434-440, 2016

Aihara M, Naito I, Shimizu T, Fujimaki H, Asakura K, Miyamoto N, Yoshimoto Y: Preoperative embolization of intracranial meningiomas using n-butyl cyanoacrylate. Neuroradiology 57:713-719, 2015

Iijima K, Hirato M, Miyagishima T, Horiguchi K, Sugawara K, Hirato J, Yokoo H, Yoshimoto Y: Microrecording and image-guided stereotactic biopsy of deep-seated brain tumors. J Neurosurg. 123:978-988, 2015

Iijima K, Kurachi M, Shibasaki K, Naruse M, Puentes S, Imai H, Yoshimoto Y, Mikuni M, Ishizaki Y : Transplanted microvascular endothelial cells promote oligodendrocyte precursor cell survival in ischemic demyelinating lesions. J Neurochem. 135:539-550, 2015

Imai H, Miyawaki S, Ono H, Nakatomi H, Yoshimoto Y, Saito N: The importance of encephalo-myo-synangiosis in surgical revascularization strategies for moyamoya disease in children and adults. World Neurosurg. 83:691-699, 2015

Miyamoto, N., Naito, I., Simizu, T. and Yoshimoto, Y: Efficacy and Limitations of Transarterial Acrylic Glue Embolization for Intracranial Dural Arteriovenous Fistulas. Neurol Med Chir (Tokyo) 55:163-172, 2015

Shimizu T, Naito I, Aihara M, Fujimaaki H, Asakura K, Miyamoto N, Yoshimoto Y: Visual outcomes of endovascular and microsurgical treatment for large or giant paraclinoid aneurysms. Acta Neurochir (Wien) 157:13–20, 2015.

Tomita Y, Tosaka M, Aihara M, Horiguchi K, Yoshimoto Y: Growth of Primary and Remnant Vestibular Schwannomas: A Three-Year Follow-Up Study. World Neurosurg. 83:937-944, 2015

Tosaka M, Sato K, Amanuma M, Higuchi T, Arai M, Aishima K, Shimizu T, Horiguchi K, Sugawara K, Yoshimoto Y: Superficial siderosis of the central nervous system caused by hemorrhagic intraventricular craniopharyngioma: case report and literature review. Neurol Med Chir (Tokyo) 55:89-94, 2015

Iijima, K, Tosaka M, Nagano T, Yaoita H, Matsumura N, Nakazato Y, Yoshimoto Y: Oculomotor nerve schwannoma associated with acute hydrocephalus: Case report. Neurol Med Chir (Tokyo) 54:654-658, 2014

Osawa T, Tosaka M, Nagaishi M, Yoshimoto Y: Factors affecting peritumoral brain edema in meningioma:special histological subtypes with prominently extensive edema. J Neurooncol 111:49-57, 2014

Aihara M, Fujimaki H, Shintoku R, Osawa T, Asakura K, Miyazaki M, Horiuchi T, Nitta J: Mattress anastomosis in micro vascular reconstruction: technical note. Acta Neurochir (Wien) 155:607-609, 2013

Iijima K, Horiguchi K, Yoshimoto Y: Microvascular decompression of the root emerging zone for hemifacial spasm: evaluation by fusion magnetic resonance imaging and technical considerations. Acta Neurochir (Wien) 155:855-862, 2013

Iijima K, Tosaka M, Nagano T, Yaoita H, Matsumura N, Nakazayto Y, Yoshimoto Y: Oculomotor nerve schwannoma associated with acute hydrocephalus: Case report. Neurol Med Chir (Tokyo) 20:1-5, 2013

Tosaka M, Sakamoto K, Watanabe S, Yodonawa M, Kunimine H, Aishima K, Fujii T, Yoshimoto Y: Critical classification of craniostomy for chronic subdural hematoma; Safer technique for hematoma aspiration. Neurol Med Chir (Tokyo) 53:273-278, 2013

Yoshimoto Y, Tanaka Y: Risk perception of unruptured intracranial aneurysms. Acta Neurochir (Wien) 155:2029-2036, 2013

Aishima K, Yoshimoto Y: Screening strategy using sequential serum D-dimer assay for the detection and prevention of venous thromboembolism after elective brain tumor surgery. British J Neurosurg 1-7. 2012

Miyagishima T, Hara T, Inoue M, Terano N, Ohno H, Okamoto K, Hasuo K: Pontine venous congestion due to dural arteriovenous fistula of the cavernous sinus;Case report and review of the literature. Surgical Neurol Int 3:53, 2012

Puentes S, Kurachi M, Shibasaki K, Naruse M, Yoshimoto Y, Mikuni M, Imai H, Ishizaki Y: Brain microvascular endothelial cell transplantation ameliorates ischemic white matter damage. Brain Research 1469:43-53, 2012

Shimizu M, Imai H, Kagoshima K, Umezawa E, Shimizu T, Yoshimoto Y: Detection of compression vessels in trigeminal neuraolgia by surface-rendering three-dimensional reconstruction of 1.5-and 3.0-T magnetic resonance imaging. World Neurosurg 378-385, 2012

Sato K, Yoshimoto Y: Risk profile of intracranial aneurysms rupture rate Is noto constant after formation. Stroke 42:3376-3381, 2011

Yamaguchi R, Hosaka M, Torii S, Saito N, Yoshimoto Y, Imai H, Takeuchi T: Cyclophilin C-associated protein regulation of phagocytic functions via NFAT activation in macrophages. Brain Res 1397:55-65. 2011

Kubota C, Torii S, Saito N, Yoshimoto Y, Imai H, Takeuchi T: Constitutive reactive oxygen species generation from autophagosome/lysosome in neuronal oxidative toxicity. J Biological Chemistry 285:667-674, 2010

Yamaguchi R, Yoshida T, Nakazato Y, Yoshimoto Y: Solitary Intraosseous Neurofibroma of the Frontal Bone -Case Report-. Neurol Med Chir (Tokyo) 50(8):683-686, 2010

Nagaki T, Sato K, Yoshida T, Yoshimoto Y: Benefit of carotid endarterectomy for symptomatic and asymptomatic severe carotid stenosis; a Markov model based on the randomized control trials. J Neurosurg 111:970-977, 2009

Nakamura M, Imai H, Konno K, Kubota C, Seki K, Puentes S, Ahmad F, Yokoo H, Hata H, Yoshimoto Y, Saito N: Experimental investigation of encephalomyosynangiosis using gyrencephalic brain of the miniature pig: histopathological ebaluation of dynamic reconstruction of vessels for functional anastomosis. J Neurosurg. Pediatrics 3;488-495, 2009

Tosaka M, Sato N, Fujimaki H, Tanaka Y, Kagoshima K, Takahashi A, Saito N, Yoshimoto Y: Diffuse pachymeningeal hyperintensity and subdural effusion/Hematoma detected by fluid-attenuated inversion recovery MR imaging in patients with spontaneous intracranial hypotension. AJNR 29:1164-1170, 2008

Yamaguchi R, Kohga H, Kurosaki M, Tamura M, Tanaka S, Tosaka M, Yoshimoto Y: Acute basilar artery occlusion in a patient with left subclavian artery occlusion due to first rib anomaly. Neurol Med Chir (Tokyo) 48;355-358, 2008

Yoshimoto Y, Tanaka Y: Biological heterogeneity and length-biased sampling in asymptomatic neurosurgical patients. Br J Neurosurg. 22:368-72, 2008

Tanaka Y, Imai H, Kenjiro K, Miyagishima T, Kubota C, Puentes S, Aoki T, Hata H, Takata K, Yoshimoto Y, Saito N: Experimental model of lacunar infarction in the gyrencephalic bain of the miniature pig     Neurological assessment and histological, immunohistochemical, and physiological evaluation of dynamic corticospinal tract deformation. Stroke 39;205-212, 2008

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