研究について

研究について

研究内容

脳腫瘍の遺伝子解析
遺伝子治療の基礎研究
虚血性神経細胞死のメカニズムの解明
脳血管攣縮のメカニズムの解明
パーキンソン病の病態解明と治療法の開発
安全な手術支援のための術中モニタリング法の開発

教育業務

<医学部>
教養教育科目(身近な医学)
医学論文作成チュートリアル(2年生)
脳神経外科系統講義(4年生)
脳神経外科臨床実習(5年生)
実践臨床病態学講義(6年生)
<大学院>
脳脊髄病態外科学講義、脳脊髄病態外科学演習、脳脊髄病態外科学実習
脳神経外科的疾患の病態、治療法の研究の統合的理解を助けるため、セミナー形式の講義、研究指導、論文作成指導を行っている。

 

業績

Tanaka Y, Imai H, Kenjiro K, Miyagishima T, Kubota C, Puentes S, Aoki T, Hata H, Takata K, Yoshimoto Y, Saito N: Experimental model of lacunar infarction in the gyrencephalic bain of the miniature pig     Neurological assessment and histological, immunohistochemical, and physiological evaluation of dynamic corticospinal tract deformation. Stroke 39;205-212, 2008

Tosaka M, Sato N, Fujimaki H, Tanaka Y, Kagoshima K, Takahashi A, Saito N, Yoshimoto Y: Diffuse pachymeningeal hyperintensity and subdural effusion/Hematoma detected by fluid-attenuated inversion recovery MR imaging in patients with spontaneous intracranial hypotension. AJNR 29:1164-1170, 2008

Yamaguchi R, Kohga H, Kurosaki M, Tamura M, Tanaka S, Tosaka M, Yoshimoto Y: Acute basilar artery occlusion in a patient with left subclavian artery occlusion due to first rib anomaly. Neurol Med Chir (Tokyo) 48;355-358, 2008

Yoshimoto Y, Tanaka Y: Biological heterogeneity and length-biased sampling in asymptomatic neurosurgical patients. Br J Neurosurg. 22:368-72, 2008

Nagaki T, Sato K, Yoshida T, Yoshimoto Y: Benefit of carotid endarterectomy for symptomatic and asymptomatic severe carotid stenosis; a Markov model based on the randomized control trials. J Neurosurg 111:970-977, 2009

Nakamura M, Imai H, Konno K, Kubota C, Seki K, Puentes S, Ahmad F, Yokoo H, Hata H, Yoshimoto Y, Saito N: Experimental investigation of encephalomyosynangiosis using gyrencephalic brain of the miniature pig: histopathological ebaluation of dynamic reconstruction of vessels for functional anastomosis. J Neurosurg. Pediatrics 3;488-495, 2009

Kubota C, Torii S, Saito N, Yoshimoto Y, Imai H, Takeuchi T: Constitutive reactive oxygen species generation from autophagosome/lysosome in neuronal oxidative toxicity. J Biological Chemistry 285:667-674, 2010

Yamaguchi R, Yoshida T, Nakazato Y, Yoshimoto Y: Solitary Intraosseous Neurofibroma of the Frontal Bone -Case Report-. Neurol Med Chir (Tokyo) 50(8):683-686, 2010

Sato K, Yoshimoto Y: Risk profile of intracranial aneurysms rupture rate Is noto constant after formation. Stroke 42:3376-3381, 2011

Yamaguchi R, Hosaka M, Torii S, Saito N, Yoshimoto Y, Imai H, Takeuchi T: Cyclophilin C-associated protein regulation of phagocytic functions via NFAT activation in macrophages. Brain Res 1397:55-65. 2011
Aishima K, Yoshimoto Y: Screening strategy using sequential serum D-dimer assay for the detection and prevention of venous thromboembolism after elective brain tumor surgery. British J Neurosurg 1-7. 2012
Miyagishima T, Hara T, Inoue M, Terano N, Ohno H, Okamoto K, Hasuo K: Pontine venous congestion due to dural arteriovenous fistula of the cavernous sinus;Case report and review of the literature. Surgical Neurol Int 3:53, 2012

Puentes S, Kurachi M, Shibasaki K, Naruse M, Yoshimoto Y, Mikuni M, Imai H, Ishizaki Y: Brain microvascular endothelial cell transplantation ameliorates ischemic white matter damage. Brain Research 1469:43-53, 2012

Shimizu M, Imai H, Kagoshima K, Umezawa E, Shimizu T, Yoshimoto Y: Detection of compression vessels in trigeminal neuraolgia by surface-rendering three-dimensional reconstruction of 1.5-and 3.0-T magnetic resonance imaging. World Neurosurg 378-385, 2012

Aihara M, Fujimaki H, Shintoku R, Osawa T, Asakura K, Miyazaki M, Horiuchi T, Nitta J: Mattress anastomosis in micro vascular reconstruction: technical note. Acta Neurochir (Wien) 155:607-609, 2013

Iijima K, Horiguchi K, Yoshimoto Y: Microvascular decompression of the root emerging zone for hemifacial spasm: evaluation by fusion magnetic resonance imaging and technical considerations. Acta Neurochir (Wien) 155:855-862, 2013

Iijima K, Tosaka M, Nagano T, Yaoita H, Matsumura N, Nakazayto Y, Yoshimoto Y: Oculomotor nerve schwannoma associated with acute hydrocephalus: Case report. Neurol Med Chir (Tokyo) 20:1-5, 2013

Osawa T, Tosaka M, Nagaishi M, Yoshimoto Y: Factors affecting peritumoral brain edema in meningioma:special histological subtypes with prominently extensive edema. J Neurooncol 111:49-57, 2014

Tosaka M, Sakamoto K, Watanabe S, Yodonawa M, Kunimine H, Aishima K, Fujii T, Yoshimoto Y: Critical classification of craniostomy for chronic subdural hematoma; Safer technique for hematoma aspiration. Neurol Med Chir (Tokyo) 53:273-278, 2013

Yoshimoto Y, Tanaka Y: Risk perception of unruptured intracranial aneurysms. Acta Neurochir (Wien) 155:2029-2036, 2013

Iijima, K, Tosaka M, Nagano T, Yaoita H, Matsumura N, Nakazato Y, Yoshimoto Y: Oculomotor nerve schwannoma associated with acute hydrocephalus: Case report. Neurol Med Chir (Tokyo) 54:654-658, 2014

Aihara M, Naito I, Shimizu T, Fujimaki H, Asakura K, Miyamoto N, Yoshimoto Y: Preoperative embolization of intracranial meningiomas using n-butyl cyanoacrylate. Neuroradiology 57:713-719, 2015
Iijima K, Hirato M, Miyagishima T, Horiguchi K, Sugawara K, Hirato J, Yokoo H, Yoshimoto Y: Microrecording and image-guided stereotactic biopsy of deep-seated brain tumors. J Neurosurg. 123:978-988, 2015

Iijima K, Kurachi M, Shibasaki K, Naruse M, Puentes S, Imai H, Yoshimoto Y, Mikuni M, Ishizaki Y : Transplanted microvascular endothelial cells promote oligodendrocyte precursor cell survival in ischemic demyelinating lesions. J Neurochem. 135:539-550, 2015

Imai H, Miyawaki S, Ono H, Nakatomi H, Yoshimoto Y, Saito N: The importance of encephalo-myo-synangiosis in surgical revascularization strategies for moyamoya disease in children and adults. World Neurosurg. 83:691-699, 2015

Miyamoto, N., Naito, I., Simizu, T. and Yoshimoto, Y: Efficacy and Limitations of Transarterial Acrylic Glue Embolization for Intracranial Dural Arteriovenous Fistulas. Neurol Med Chir (Tokyo) 55:163-172, 2015

Shimizu T, Naito I, Aihara M, Fujimaaki H, Asakura K, Miyamoto N, Yoshimoto Y: Visual outcomes of endovascular and microsurgical treatment for large or giant paraclinoid aneurysms. Acta Neurochir (Wien) 157:13–20, 2015.

Tomita Y, Tosaka M, Aihara M, Horiguchi K, Yoshimoto Y: Growth of Primary and Remnant Vestibular Schwannomas: A Three-Year Follow-Up Study. World Neurosurg. 83:937-944, 2015

Tosaka M, Sato K, Amanuma M, Higuchi T, Arai M, Aishima K, Shimizu T, Horiguchi K, Sugawara K, Yoshimoto Y: Superficial siderosis of the central nervous system caused by hemorrhagic intraventricular craniopharyngioma: case report and literature review. Neurol Med Chir (Tokyo) 55:89-94, 2015

Ibe Y, Tosaka M, Horiguchi K, Sugawara K, Miyagishima T, Hirato M, Yoshimoto Y: Resection extent of the supplementary motor area and post-operative neurological deficits in glioma surgery. Br J Neurosurg. Jan 13:1-7. [Epub ahead of print], 2016

Matsuzaki Y, Konno A, Mukai R, Honda F, Hirato M, Yoshimoto Y, Hirai H: Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors. Mol Neurobiol. Feb 16. [Epub ahead of print], 2016

Torii S, Shintoku R, Kubota C, Yaegashi M, Torii R, Sasaki M, Suzuki T, Mori M, Yoshimoto Y, Takeuchi T, Yamada K: An essential role for functional lysosomes in ferroptosis of cancer cells.
Biochem J. 473:769-777, 2016

Yamaguchi R, Kohga H, Tosaka M, Sekine A, Mizushima K, Harigaya Y, Yoshimoto Y : A Case of Optic Neuritis Concomitant with Pituitary Tumor During Pregnancy. World Neurosurgery. Sep;93:488, 2016 

Tanaka Y, Tosaka M, Fujimaki H, Honda F, Yoshimoto Y : Sex- and Age-Related Differences in the Clinical and Neuroimaging Characteristics of Patients With Spontaneous Intracranial Hypotension: A Records Review. Headache. Sep;56(8):1310-6, 2016

Aishima K, Shimizu T, Aihara M, Yoshimoto Y : Lifetime Effects of Small Unruptured Intracranial Aneurysms. World Neurosurg. Nov;95:434-440, 2016

Nakata S, Horiguchi K, Ishiuchi S, Yoshimoto Y, Yamada S, Nobusawa S, Ikota H, Hirato J, Yokoo H : A case of high-grade astrocytoma with BRAF and ATRX mutations following a long-standing course over two decades. Neuropathology. Feb 9, 2017 

Horiguchi K, Tosaka M, Higuchi T, Arisaka Y, Sugawara K, Hirato J, Yokoo H, Tsushima Y, Yoshimoto Y : Clinical value of fluorine-18α-methyltyrosine PET in patients with gliomas: comparison with fluorine-18 fluorodeoxyglucose PET. EJNMMI Res. Dec;7(1):50,  2017  

Tosaka M, Higuchi T, Horiguchi K, Osawa T, Arisaka Y, Fujita H, Tsushima Y, Yoshimoto Y : Preoperative Evaluation of Sellar and Parasellar Macro-lesions by Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography. World Neurosurg. Apr 17, 2017

Osawa S, Kurachi M, Yamamoto H, Yoshimoto Y, Ishizaki Y : Fibronectin on extracellular vesicles from microvascular endothelial cells is involved in the vesicle uptake into oligodendrocyte precursor cells. Biochem Biophys Res Commun. 488(1):232-238, 2017

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